Bruce E. Kirkpatrick

MD-PhD student interested in surgery-science, tissue engineering, and regenerative medicine.

Aurora, Colorado | bruce.kirkpatrick@colorado.edu | (360) 562-6308 | @bruceekirk

Education

University of Colorado Anschutz Medical Campus
2018-26 MD-PhD Student, Medical Scientist Training Program

University of Colorado Boulder
2020-24 PhD, Biological Engineering, Anseth Research Group

2019 PhD Rotation, Bowman Research Group
Synthesized novel monomers for biofunctional immolative hydrogel development.

2018 PhD Rotation, Anseth Research Group
Developed a workflow for reliable SU-8 3050 photolithography towards fabricating microfluidics devices for modular granular hydrogel synthesis.

2013-17 Bachelor of Science with honors, Chemical and Biological Engineering
Minor in Business Analytics, Leeds School of Business

Publications

Academic

2020Toward Stimuli‐Responsive Dynamic Thermosets through Continuous Development and Improvements in CANs
Podgorski M, Fairbanks BD, Kirkpatrick BE, McBride MK, Martinez A, Dobson A, Bongiardina NJ, Bowman CN.
Advanced Materials, 2020; doi:10.1002/adma.201906876. Featured cover art: doi:10.1002/adma.202070158.

2019CyP-D Knockout Protects the Mouse Kidney Against CsA-Induced Oxidative Stress and DNA Hypomethylation
Klawitter Je, Klawitter Jo, Pennington A, Kirkpatrick B, Roda GF, Kotecha NC, Thurman JM, Christans U.
AJP Renal, 2019; doi:10.1152/ajprenal.00417.2018.

2018PTEN deficiency promotes pathological vascular remodeling of human coronary arteries
Moulton KS, Li M, Strand K, Burgett S, McClatchey P, Tucker R, Furgeson SB, Lu S, Kirkpatrick B, Cleveland JC, Nemenoff RA, Ambardekar AV, Weiser-Evans MCM.
JCI Insight, 2018; doi:10.1172/jci.insight.97228.

Reports

2019Surviving Human Body Block and Graduate Core,Kirkpatrick BE.

2017Coker Gas Plant Design” (ExxonMobil plant design)
Magnuson E, Burns A, Kirkpatrick BE, Roda G, Miksch C.

2016Vinyl Chloride Production” (Chemical engineering plant design)
Karasek L, Kirkpatrick BE, Lipsey A, Siahpush K.

Terpene and Terpenoid Biosynthesis” (Metabolic engineering)
Kirkpatrick BE, Roda G, Sterling C.

2015Honeybee Flight: An Inquiry” (Fluid dynamics)
Kirkpatrick BE, Payne S, Ritz C, Doan P, McDaniel J.

Proposals

2019Carbon Monoxide Mediates Preeclamptic Phenotypes in Human Placental Tissues,” Kirkpatrick BE.

2018 “Applied Asymmetric Cell Division for Induced Myogenesis,” Kirkpatrick BE, Culp-Hill R.

Non-academic

201970 years ago, physicians used a heart defect to fix blue babies.Kirkpatrick B. massivesci.com.

2017Frequent Flyer: Why Isn’t Dad Dead Yet?Kirkpatrick B. Journal 2020. 5:31-38.

Unpublished

2017 “Nondestructive Evaluation of Gold Nanoparticle Uptake by Mammalian Cells,” [abstract]
Kirkpatrick, White, Jeerage. Prepared before dissolution of Materials for Biological Environments Group.

2016 “Mechanocatalysis of a Claisen Rearrangement,” Kumar, Weidner, Kirkpatrick, Goodwin.
Project ended when Kumar accepted a position at Tata Institute of Fundamental Research.

2015 “Quantified Distribution of Nrp2-Targeted AuNR,” Kirkpatrick, Li, Tian, Wang, Ranville, Boyes, Moulton.
Manuscript led to experiments described in “PTEN deficiency promotes pathological vascular remodeling.

Figure Donations

2018Genomics and transcriptomics of megakaryocytes and platelets: Implications for health and disease
Fisher M, Di Paola J. Res Pract Thromb Haemost, 2018;00:1–10. Contributed Figure 1.

2015ETV6 mutations define a new cancer predisposition syndrome
Kirkpatrick G, Noetzli L, Di Paola J, Porter CC. Oncotarget, 2015;6(19):16830-16831. Contributed Figure 1.

Presentations

Talks

2020Implementing Covalent Adaptable Networks for Biomedical Applications,” B Kirkpatrick, CU MSTP Retreat

2019 “Synthesizing Novel Monomers Towards Self-Immolative Gels,” B Kirkpatrick, MSTP Rotation Talk.

“Surviving Human Body Block and Graduate Core,” Kirkpatrick BE.

2018 “Bioprinting Modular Granular Hydrogels,” B Kirkpatrick, MSTP Rotation Talk.

2017 “Coker Gas Plant Design” (ExxonMobil senior design project),
B Kirkpatrick, E Magnuson, A Burns, G Roda, C Miksch.

Phillips v. AWH Corp: Patent Claim Construction,” B Kirkpatrick, E Magnuson.

2016Non-Destructive Quantitation of AuNP Uptake by Microplate Reader Absorbance Analysis,” B Kirkpatrick, K Jeerage, S McCallan.

Posters

2019 “Bioprinting Modular Granular Hydrogels”
Kirkpatrick, Miksch, Anseth Research Group; presented at 2019 CU MSTP Retreat and National MD-PhD Student Conference by Kirkpatrick.

2018 “Cyclophilin D Knockout Protects the Mouse Kidney against Cyclosporine-Induced Oxidative Stress and DNA Hypomethylation”
Kirkpatrick, Klawitter, Pennington, Thurman, Kotecha, Christians, Klawitter; presented at Anesthesiology conference by Kirkpatrick.

2017 “Effect of 1,8-dihydroxyanthraquinone on Drosophila melanogaster development”
B Kirkpatrick, J Moon; presented at Clinical Undergraduate Research Experience Symposium.

2016Neuropilin 2-Targeted Nanoparticles Bind Selectively to Plaque Neovascularization in Atherosclerotic Arteries”
Kirkpatrick, Li, Tian, Wang, Ranville, Tuder, Boyes, Moulton; presented at International Vascular Biology Meeting by Moulton.

2014 “Molecular Zipcodes of Vasa Vasorum Neovascularization in Atherosclerosis and Diabetes”
Li, Jones, Kirkpatrick, Chaudhary, Demos-Davies, Tuder, Taylor, Boyes, Moulton; presented at CCTSI Summit II by Moulton.

Video Essays

2017 Re-Recording the Record: Pseudotranslation and Pseudotranscription in Media and Reality
I discuss the effects of logical failings inherent to a pseudotranslated or pseudotranscribed medium and the paradoxically ameliorative response derived from these flaws on the medium itself (abstract / script / references).

2016 Don’t Trust Your Ears: Physical and Digital Sound Manipulation
I explain the concepts of sound generation and manipulation while highlighting the differences in the physical function of several instruments: violin, trumpet, and clarinet (proposal / script / references). Don’t Trust Your Ears was awarded the CU Boulder Mackison Writing Award.

Employment

2017-18 iC42 Clinical Research and Development
Investigated biomarkers of aging in immunocompromised humans and Ppif -/- mice.
Extracted biological samples and conducted ‘omics’ analysis using LC-MS, Analyst, and MultiQuant.

2016-17 Jeerage Laboratory, NIST | Materials for Biological Environments Group
Developed a non-destructive quantitation method for cellular nanoparticle uptake using absorbance analysis.
Functionalized gold nanoparticles with PEG-thiol and performed characterization with DLS/Zetasizer.

2014-16 Goodwin Research Group | University of Colorado Boulder
Performed organic synthesis to functionalize anthraquinone-based monomers.
Generated neat Claisen rearrangment products and isolated specific isomers with preparatory TLC.

2015 Weiser-Evans Research Group | University of Colorado Anschutz Medical Campus
Explored PTEN, α-SMA, Nrp1/2, and CD34 expression in human atheromas with IHC and confocal microscopy.
Quantified relative gene expression and colocalization using ImageJ to characterize vessel phenotypes.

2014-15 Moulton Research Group | University of Colorado Anschutz Medical Campus
Applied untargeted and Nrp2-targeted gold nanorods in vitro and in vivo in a 17-mouse study.
Analyzed biodistribution of targeted nanorods with LC-MS and quantified in vitro uptake using epifluorescence.

Skills

Analytical

Technical

Software

Grants and Awards

2018-20 T32 Predoctoral Training Grant | National Institutes of Health

2013-17 Joseph A. Sewall Award | University of Colorado Boulder

2016 Summer Undergraduate Research Fellowship | National Institute of Standards and Technology

2015 Southwest Affiliate Undergraduate Student Research Program | American Heart Association

2014 Clinical Undergraduate Research Experience Grant | University of Colorado Boulder

Selected Activities

2020 Technology coordinator | University of Colorado MSTP Second Annual Retreat

2019-20

Project lead | University of Colorado MSTP logo redesign (sold nearly $10k of jackets featuring the new logo)

Mentor | Bryant-Webster Dual Language School

2019 First prize | University of Colorado Interprofessional Education Ethics Case Competition
“Detainees, Refugees, Patients: Complex Bioethics in Immigrant Healthcare,” Kirkpatrick, Roda, Santiago-Moreno.

Mentor | VistaPEAK High School Senior Design Class; built an evidence-based project-help website.

Volunteer | Think Like A Scientist; after-school course for underprivliged third-grade girls.

2018-19 First trumpet, viola | Anschutz Medical Campus Orchestra

2018 First prize | University of Colorado Interprofessional Education Ethics Case Competition
“Vaccines, Biological Weapons, and Dual-Use Research,” Forman, Kirkpatrick, Roda, Santiago-Moreno, Skillin, Turner.

Teacher | Bricks for Kids (after-school elementary science education program using LEGOs)

2017 Volunteer | Denver Health Emergency Department and Adult Urgent Care

Finalist | Center for Education on Social Responsibility Business Ethics Case Competition

2014-17 Tutor | transport phenomenon, engineering maths, humanities, sociology

2016 Outstanding Delegate & Outstanding Delegation | New York National Model United Nations
Represented Guyana in Economic Commission for Latin America and the Caribbean.

2013-15 First trumpet, fourth trumpet | University of Colorado Thompson Jazz Studies Program Big Bands

Conferences Attended

2019 National MD-PhD Student Conference

2018 Boulder Jazz Trumpet Consortium

Presenting Data and Information | hosted by Edward Tufte

National MD-PhD Student Conference

2017 University of Colorado Boulder CURE Symposium

2016 Denver Jazz Trumpet Consortium

Music

I have extensive performance experience playing trumpet and violin and can competently play clarinet, saxophone, valve trombone, and viola.

BEK20200715